Press preview | 15 September 2022 | 10 am – 2 pm

Introduction by Professor Giancarlo Comi

Exhibition: 16 Sep – 10 Oct 2022

Largo Isarco, 2, 20139 Milano



“Preserving the Brain” is a forum on neurodegenerative diseases to be held in September and October 2022, as the fourth phase of “Human Brains,” Fondazione Prada’s neuroscience project. Realized in collaboration with thirteen of the most prestigious international neuroscience institutes and universities, “Human Brains: Preserving the Brain – Forum on Neurodegenerative Diseases”

Exhibition: 16 September – 10 October 2022

Conference: 6 and 7 October 2022

Fondazione Prada’s Milan premises.

“Preserving the Brain” aims to stimulate an open and critical exchange between international scientists and experts on neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, Amyotrophic lateral sclerosis and Multiple sclerosis, which are widely spread and as yet incurable. The forum participants will include researchers, patient associations, and representatives of health care institutions and the pharmaceutical and biotechnology industries. They will debate the current state of knowledge of these diseases and the tools currently used to fight them, while also seeking to identify lacunae in the search for possible therapies, and jointly defining priorities and strategies to sustain scientific research.

As stated by Miuccia Prada, President of Fondazione Prada, “For us, this phase of the project is particularly significant as it permits a closer understanding of scientific research’s impact on our everyday lives, and in particular on the discovery of possible cures and treatments. ‘Preserving the Brain’ also demonstrates how critical collaboration and sharing of knowledge are within the scientific community. This first international forum could become recurring and allow the organizations we are associated with to communicate with a wider audience, as they would like to, and Fondazione Prada to contribute tangibly to neuroscientific research.”

Glass Brain Project: visualizing brain activity in 3D. Credit Neuroscape / UCSF Weill Institute for Neurosciences. Courtesy University of California, San Francisco, USA

As underlined by Giancarlo Comi, President of the “Human Brains” scientific board, “The exhibition and conference that comprise the ‘Preserving the Brain’ project have been developed with the goal of finding a common strategy to protect the brain from neurodegenerative diseases. New technological developments have markedly increased knowledge of the biology that underlies these diseases, and potential targets for new treatments are taking shape.”

The pivotal moment of “Preserving the Brain” will be the scientific conference held on 6 and 7 October 2022, at Fondazione Prada’s Cinema in Milan. Giancarlo Comi has conceived this initiative in dialogue with the thirteen research institutes involved in the project.

Each day will be divided into four thematic sessions, each one featuring three lectures and an open discussion between the scientists and researchers. The second day will end with a round table discussion in which scholars, technology experts, representatives from the pharmaceutical industry and patient advocacy associations will discuss future challenges in developing new therapies. The speakers will explore the subject of neurodegenerative diseases from different perspectives, such as genetic implications and molecular mechanisms, clinical trials and possible drug treatments. The conference is addressed to researchers and universities involved in the project and representatives of prominent institutions in the health sector. The sessions will also be streamed and visible to all on the online platform dedicated to Human Brains.

Exhibition: 16 September – 10 October 2022

in the Podium, the space at the center of Fondazione Prada’s Milan venue.

Heterogeneous remyelination profiles in 3 subjects with MS (Demyelination in red; Remyelination in blue). Courtesy Hôpital de la Pitié-Salpêtrière, Sorbonne University AP-HP, Neurology department and Paris Brain Institute, Paris, France

Conceived by the New York studio 2×4, the exhibition design will be divided into different sections supervised by the research centers, and a common central area that will encourage dialogue and exchanges between the thirteen institutes. Each section will examine a specific research process on neurodegenerative diseases employing video presentations, technological objects and instruments, scientific documents, and visual materials. The exhibition aims to explore the complexity of scientific research by retracing the stages from identifying therapeutic targets to the different phases in the validation of new therapies to the availability of a drug for the patient. Special attention will be given to personalized medicine, a new approach that recognizes the uniqueness of the individual and treats the person suffering from a disease rather than a disease manifested in a person, thus optimizing the use of drugs and the treatment monitoring.

Harvard Medical School, Brigham and Women’s Hospital, Ann Romney Center for Neurological Diseases, Boston, United States; Hôpital de la Pitié-Salpêtrière, Sorbonne University AP-HP, Neurology department and Paris Brain Institute, Paris, France; UniSR – Università Vita-Salute San Raffaele, Milan, Italy; Juntendo University Hospital, Neurology Department, Tokyo, Japan; Karolinska Institutet, Stockholm, Sweden; German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association, Bonn, Germany; Max Planck Institute of Neurobiology, Munich, Germany; Montreal Neurological Institute-Hospital, McGill Research and Teaching Institute, Canada; Tianjin Medical University General Hospital, Neurology Department, Tianjin, China; UCSF Weill Institute for Neuroscience, University of California, San Francisco, United States; University College London, United Kingdom; Weizmann Institute of Science, Revohot, Israel; Yale School of Medicine, New Haven, United States.



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